Ghostface released a collaborative album with D-Block member Sheek Louch called Wu Block. The album was released on November 27, 2012, on E1 Music and debuted at number 73 on the US Billboard 200 chart, with first-week sales of 8,600 copies in the United States.
In an interview with Complex Magazine on November 17, 2012, Ghostface Killah confirmed that he has left Def Jam, making Apollo Kids his last album on the label. In the same interview he also stated that Blue & Cream, the sequel to his critically acclaimed album Supreme Clientele, is 80-85 percent done. On April 16, 2013, Ghostface released his tenth album Twelve Reasons to Die which was produced by Adrian Younge and executive produced by RZA. The album was released in various formats such as CD, vinyl and cassette under RZA's Soul Temple Records. The deluxe digital and CD versions also come with a comic book.
He would later announce that the sequel to Supreme Clientele would be released between July and September 2013 and that his collaborative album with MF Doom would be released around Halloween 2013] though neither projects materialized. In January 2014, he appeared on the VH1 series Couples Therapy with his girlfriend Kelsey Nykole. Later that year Ghostface announced he would be releasing his eleventh album titled 36 Seasons in December 2014. He collaborated with Canadian jazz band BADBADNOTGOOD on an album titled Sour Soul which was released in 2015.
A sequel to Twelve Reasons to Die, simply titled Twelve Reasons to Die II, was released on July 10, 2015.
Ghostface new album The Lost Tapes is scheduled to be released 2018.